Low serum testosterone levels are poor predictors of sexual dysfunction

3 min

Background

Testosterone supplementation in older men with age-related reduced testosterone levels (as opposed to established clinical androgen deficiency) to help with various ailments, including sexual dysfunction, is controversial and not backed by good evidence.

The association between testosterone levels and sexual dysfunction in older men remains poorly defined and other factors such as chronic diseases including diabetes and obesity may be more important predictors of sexual problems.

Aim

To identify predictors of sexual dysfunction using baseline data from the reduction by dutasteride of prostate cancer events (REDUCE) study.

Methods

REDUCE was a 4-year randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of once-daily dutasteride 0.5 in over 8000 men aged 50-75 years with a prostate-specific antigen (PSA) level of 2.5-10 ng/mL (50-60 years) or 3.0-10 ng/mL (>60 years) and a negative prostate biopsy within 6 months of enrolment.

Baseline values (mean serum testosterone, age, International Prostate Symptom Score [IPSS, a measure of lower urinary tract symptoms], total prostate volume [TPV], body mass index [BMI], and presence of diabetes/glucose intolerance) were compared in subjects with and without sexual dysfunction (sexual inactivity, impotence, decreased libido or a Problem Assessment Scale of the Sexual Function Index [PAS-SFI] score <9 indicating a ‘small problem’ in at least one of sexual inactivity, impotence or decreased libido).

Results

Multivariate logistic regression showed that baseline age and IPSS were significant predictors of all four sexual function criteria examined (P<0.0001).

BMI was a significant predictor of decreased libido, impotence and a PAS-SFI score <9, while diabetes/glucose intolerance was a significant predictor of sexual inactivity, impotence and a PAS-SFI score < 9. Testosterone and TPV were not significant predictors of any sexual function criterion examined.

Conclusion

Age, IPSS, BMI and diabetes/glucose intolerance, but not serum testosterone or TPV, were significant independent predictors of sexual dysfunction in the REDUCE study population.

The lack of association between sexual dysfunction and serum testosterone questions the value of modestly reduced or low normal testosterone levels as criteria for choosing testosterone replacement in older men with sexual dysfunction.


Did you find this page helpful?

Sign up to our newsletter

We release two monthly newsletters – one written for men, family and friends, and another for health practitioners.

Your preferred mailing list

Your name

Your email

Stay up to date

FacebookInstagramLinkedinTwitterYoutubespotifytiktok

Healthy Male acknowledges the traditional owners of the land. We pay our respects to elders past, present and future. We are committed to providing respectful, inclusive services and work environments where all individuals feel accepted, safe, affirmed and celebrated.

Disclaimer

Healthy Male is funded by the Australian Government Department of Health and Aged Care. This website does not host any form of advertisement. Information provided on this website is not a substitute for medical advice.

Trusted information partner of