The future of focal therapy for prostate cancer treatment

The outcomes for patients diagnosed with prostate cancer depend on more than just rates of cure or survival. A considerable burden is experienced by men who require treatment for prostate cancer, in many cases arising from complications of the procedures themselves.

The Impact of Prostate Cancer Treatment

Many men who undergo surgery or radiation therapy have worse urinary, bowel (respectively), and erectile function after treatment than they did before¹, which can have a substantial negative effect on their mental health². Refinement of treatment approaches to prostate cancer has drastically improved survival over the past 20-30 years, but this has come with the cost of long-term morbidity for many men.

With advanced medical imaging techniques, such as multiparametric MRI⁴, specific targeting of prostate cancer tumours has become possible.

Focal Therapy: A Potential Solution

Focal therapy, in which targeted ablation of only cancerous tissue is achieved (using, for example, high-intensity focused ultrasound, cryotherapy, or laser), offers the possibility of good outcomes in terms of metastasis- and cancer-free survival, and avoidance of treatment complications, in men with low or intermediate stage localised prostate cancer.

The Future of Prostate Cancer Care

Unfortunately, there are currently no data available from randomised trials of focal therapy versus prostatectomy to guide practice; these will come soon, from at least three prospective clinical trials. Until then, patients should be encouraged by the continuing advances in prostate cancer treatment, and the potential of good long-term treatment outcomes from the point of view of survival and quality of life.

References

_{[1] Korfage, I.J., Essink-Bot, M.-L., Borsboom, G.J.J.M., Madalinska, J.B., Kirkels, W.J., Habbema, J.D.F., Schröder, F.H., and De Koning, H.J., 2005. Five-year follow-up of health-related quality of life after primary treatment of localized prostate cancer. International Journal of Cancer, 116 (2), 291–296.}

_{[2] Ilie, G., White, J., Mason, R., Rendon, R., Bailly, G., Lawen, J., Bowes, D., Patil, N., Wilke, D., Macdonald, C., Rutledge, R., and Bell, D., 2020. Current Mental Distress Among Men With a History of Radical Prostatectomy and Related Adverse Correlates. American Journal of Men’s Health, 14 (5), 155798832095753.}

_{[3] Ilic, D., Evans, S.M., Allan, C.A., Jung, J.H., Murphy, D., and Frydenberg, M., 2017. Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer. Cochrane Database of Systematic Reviews.}

_{[4] Sun, Y., Reynolds, H.M., Parameswaran, B., Wraith, D., Finnegan, M.E., Williams, S., and Haworth, A., 2019. Multiparametric MRI and radiomics in prostate cancer: a review. Australasian Physical & Engineering Sciences in Medicine, 42 (1), 3–25.}

_{[5] Guillaumier, S., Peters, M., Arya, M., Afzal, N., Charman, S., Dudderidge, T., Hosking-Jervis, F., Hindley, R.G., Lewi, H., Mccartan, N., Moore, C.M., Nigam, R., Ogden, C., Persad, R., Shah, K., Van Der Meulen, J., Virdi, J., Winkler, M., Emberton, M., and Ahmed, H.U., 2018. A Multicentre Study of 5-year Outcomes Following Focal Therapy in Treating Clinically Significant Nonmetastatic Prostate Cancer. European Urology, 74 (4), 422–429.}

_{[6] Faure Walker, N.A., Norris, J.M., Shah, T.T., Yap, T., Cathcart, P., Moore, C.M., Ahmed, H.U., Emberton, M., and Minhas, S., 2018. A comparison of time taken to return to baseline erectile function following focal and whole gland ablative therapies for localized prostate cancer: A systematic review. Urologic Oncology: Seminars and Original Investigations, 36 (2), 67–76.}

_{[7] Shah, T.T., Reddy, D., Peters, M., Ball, D., Kim, N.H., Gomez, E.G., Miah, S., Evans, D.E., Guillaumier, S., Van Rossum, P.S.N., Van Son, M.J., Hosking-Jervis, F., Dudderidge, T., Hindley, R., Emara, A., Mccracken, S., Greene, D., Nigam, R., Mccartan, N., Valerio, M., Minhas, S., Afzal, N., Lewi, H., Ogden, C., Persad, R., Virdi, J., Moore, C.M., Arya, M., Emberton, M., Ahmed, H.U., and Winkler, M., 2021. Focal therapy compared to radical prostatectomy for non-metastatic prostate cancer: a propensity score-matched study. Prostate Cancer and Prostatic Diseases.}