Can men with Klinefelter syndrome father kids?

6 min

Related conditions

Klinefelter syndrome is the most common chromosomal disorder in men, occurring in up to one in 500 newborn boys. Many men go undiagnosed throughout their lives. For some men with Klinefelter syndrome, the condition is picked up when they try to start a family. This is because even for those with mild symptoms, most men with Klinefelter syndrome produce very few or no sperm and are infertile.

This can be distressing news for many men but while you almost certainly won’t be able to conceive naturally, having a family can be possible with medical assistance. Here’s how men with Klinefelter syndrome can have biological children.

Why can’t men with Klinefelter syndrome have children naturally?

Your testes have two jobs: to make the hormone testosterone and to make sperm. Both of these functions are important for fertility and are impaired by Klinefelter syndrome. Although the degree of impact on testicular function varies from person to person, extremely low or absent sperm production is common in men with Klinefelter syndrome.

How can men with Klinefelter syndrome have kids?

Some men with Klinefelter syndrome can biologically father a child through the use of assisted reproductive technology.

If you have mosaic Klinefelter there may be a very small numbers of sperm present in your semen it may be possible to use these to fertilise your partner’s eggs as part of in vitro fertilisation (IVF) treatment called Intracytoplasmic Sperm Injection (ICSI) – the injection of a single sperm into an egg for fertilisation.

In around 50% of men with Klinefelter syndrome, it will be possible for a fertility specialist to retrieve sperm[1], which can be frozen or used to fertilise your partner’s eggs and create an embryo through ICSI. These embryos are then transferred to your partner’s uterus with the hope that a pregnancy will occur. In these cases, the live birth rate per embryo transfer is similar to the success rate for men without Klinefelter syndrome who have sperm counts close to zero — around 20-25% per cycle[2].

We can’t accurately predict which Klinefelter’s men will have a successful SSR and therefore be able to use ICSI to conceive a child.

“It’s likely that if you have the micro-TESE operation earlier in life, rather than in your forties or fifties, you’re more likely to find sperm.”

– says Prof Robert McLachlan AM, andrologist and Medical Director of Healthy Male

Is Klinefelter syndrome passed down?

Klinefelter syndrome is not an inherited condition. The genetic risk to the children of men with the condition is similar to that of other men with non-obstructive azoospermia[3]. “Interestingly the great majority of testicular sperm from Klinefelter men have a normal chromosome number and so their son and daughter have a normal chromosome pattern,” Prof McLachlan says. “Yet genetic counselling is still offered.”

When should you make decisions about your fertility if you have Klinefelter syndrome?

“Worldwide figures suggest that less than half of men with Klinefelter are ever diagnosed,” Prof McLachlan says.

It’s often picked up at fertility clinics after a couple isn’t able to conceive naturally.

“One in every seven men who come to a fertility clinic with a zero sperm count has Klinefelter, and some are aware of it, but many are unaware of it,” Rob says.

If this is the case for you, and you’re yet to start testosterone replacement treatment, you should consider the next steps of fertility treatment as soon as possible.

Coming off testosterone treatment can be tough as symptoms of androgen deficiency will return, such as fatigue and low sex drive. This can be challenging when you’re used to feeling well on testosterone. You go back on testosterone as soon as the SRR is performed.

“There’s a bit of a debate as to whether you pre-empt by doing the surgery before testosterone, or simply stop testosterone treatment when life moves on a bit and you’re able to make an informed decision,” Rob says. “That’s very much a discussion to have with your specialist.”

Other pathways to parenthood

If you have Klinefelter syndrome and you’re infertile, there are other ways to start a family. These include the use of donor sperm and assisted reproductive technology, adoption or fostering. You can discuss this further with your doctor and fertility specialists.

If you’re struggling with the likelihood that you can’t create a family in the way you imagined, chatting with a counsellor or psychologist can help.


[1]Aksglaede, L., & Juul, A. (2013). Testicular function and fertility in men with Klinefelter syndrome: a review. European journal of endocrinology, 168(4), R67–R76.

[2] Yarali, H., Polat, M., Bozdag, G., Gunel, M., Alpas, I., Esinler, I., Dogan, U., & Tiras, B. (2009). TESE-ICSI in patients with non-mosaic Klinefelter syndrome: a comparative study. Reproductive biomedicine online, 18(6), 756–760.

[3] Fullerton, G., Hamilton, M., & Maheshwari, A. (2010). Should non-mosaic Klinefelter syndrome men be labelled as infertile in 2009?. Human reproduction (Oxford, England), 25(3), 588–597.

[4] S. Franik, Y. Hoeijmakers, K. D’Hauwers, D.D.M. Braat, W.L.M. Nelen, D. Smeets, H.L. Claahsen – van der Grinten, L. Ramos, K. Fleischer, Klinefelter syndrome and fertility: sperm preservation should not be offered to children with Klinefelter syndrome, Human Reproduction, Volume 31, Issue 9, September 2016, Pages 1952–1959,


Health practitioners
Klinefelter syndrome

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